PrimePCR™ ddPCR™ Expression EvaGreen® Assay: PDP1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0002598; Exonic

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5001276
Chromosome Location:   8:94934303-94934416question
Amplicon Length:   84

Gene Information

Pyruvate dehydrogenase (E1) is one of the three components (E1 E2 and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit encoded by this gene is the former and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq Jun 2009]

Gene Symbol:   PDP1
Gene Name:   pyruvate dehyrogenase phosphatase catalytic subunit 1
Aliases:   FLJ32517, FLJ56179, MGC119646, PDH, PDP, PDPC, PPM2C
RefSeq:   NC_000008.10 NT_008046.16 NG_012233.1
Ensembl:   ENSG00000164951
Entrez:   54704
UniGene:   Hs.22265
Chromosome Mapping:   8q22.1

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