PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CASP8, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0001959; Exonic

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5000771
Chromosome Location:   2:202131251-202131399question
Amplicon Length:   119

Gene Information

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain a large protease subunit and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described although not all variants have had their full-length sequences determined. [provided by RefSeq Jul 2008]

Gene Symbol:   CASP8
Gene Name:   caspase 8, apoptosis-related cysteine peptidase
Aliases:   ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473
RefSeq:   NC_000002.11 NT_005403.17 NG_007497.1
Ensembl:   ENSG00000064012
Entrez:   841
UniGene:   Hs.599762
Chromosome Mapping:   2q33-q34

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