PrimePCR™ ddPCR™ Expression Probe Assay: KLRK1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0041092; Intron-spanning

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5193347
Chromosome Location:   12:10539562-10541549question
Amplicon Length:   198

Gene Information

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C member 4) family member in the same cluster. [provided by RefSeq Dec 2010]

Gene Symbol:   KLRK1
Gene Name:   killer cell lectin-like receptor subfamily K, member 1
Aliases:   CD314, D12S2489E, FLJ17759, FLJ75772, KLR, NKG2-D, NKG2D
RefSeq:   NC_000012.11 NG_027762.1 NT_009714.17
Ensembl:   ENSG00000213809
Entrez:   22914
UniGene:   Hs.387787
Chromosome Mapping:   12p13.2-p12.3

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