PrimePCR™ ddPCR™ Expression Probe Assay: LGMN, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050069; exonic

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5191794
Chromosome Location:   14:93185177-93199070question
Amplicon Length:   60

Gene Information

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq Jul 2008]

Gene Symbol:   LGMN
Gene Name:   legumain
Aliases:   AEP, LGMN1, PRSC1
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000100600
Entrez:   5641
UniGene:   Hs.18069
Chromosome Mapping:   14q32.1

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