PrimePCR™ ddPCR™ Expression Probe Assay: FOLH1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049804; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5191774
Chromosome Location:   11:49175808-49175957question
Amplicon Length:   120

Gene Information

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq Jul 2010]

Gene Symbol:   FOLH1
Gene Name:   folate hydrolase (prostate-specific membrane antigen) 1
Aliases:   FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
RefSeq:   NC_000011.9 NT_009237.18
Ensembl:   ENSG00000086205
Entrez:   2346
UniGene:   Hs.654487
Chromosome Mapping:   11p11.2

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