PrimePCR™ ddPCR™ Expression Probe Assay: CYP2D6, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0041377; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5191533
Chromosome Location:   22:42526633-42526848question
Amplicon Length:   186

Gene Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine an adrenergic-blocking drug; sparteine and propafenone both anti-arrythmic drugs; and amitryptiline an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   CYP2D6
Gene Name:   cytochrome P450, family 2, subfamily D, polypeptide 6
Aliases:   CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, MGC120389, MGC120390, P450-DB1, P450C2D, P450DB1
RefSeq:   NC_000022.10 NG_003180.2 NG_008376.1 NT_011520.12
Ensembl:   ENSG00000100197
Entrez:   1565
UniGene:   Hs.648256
Chromosome Mapping:   22q13.1

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