PrimePCR™ ddPCR™ Expression Probe Assay: HLA-C, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0040063; exonic

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5190649
Chromosome Location:   6:31236823-31237124question
Amplicon Length:   107

Gene Information

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide exons 2 and 3 encode the alpha1 and alpha2 domain which both bind the peptide exon 4 encodes the alpha3 domain exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq Jul 2008]

Gene Symbol:   HLA-C
Gene Name:   major histocompatibility complex, class I, C
Aliases:   D6S204, FLJ27082, HLA-Cw, HLA-JY3, HLC-C, PSORS1
RefSeq:   NT_167245.1 NT_167248.1 NT_167249.1 NC_000006.11 NG_002397.2 NT_007592.15 NT_113891.2 NT_167246.1 NT_167247.1
Ensembl:   ENSG00000204525
Entrez:   3107
UniGene:   Hs.654404
Chromosome Mapping:   6p21.3

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