PrimePCR™ ddPCR™ Expression Probe Assay: KIR2DL4, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0039964; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5190508
Chromosome Location:   19:55317577-55317667question
Amplicon Length:   61

Gene Information

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes although several "framework" genes are found in all haplotypes (KIR3DL3 KIR3DP1 KIR3DL4 KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq Jul 2008]

Gene Symbol:   KIR2DL4
Gene Name:   killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
Aliases:   CD158D, G9P, KIR103, KIR103AS
RefSeq:   NC_000019.9 NG_005990.1 NG_005994.1 NG_021414.1 NT_011109.16
Ensembl:   ENSG00000189013
Entrez:   3805
UniGene:   Hs.661219
Chromosome Mapping:   19q13.4

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