PrimePCR™ ddPCR™ Expression Probe Assay: DMTF1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0039279; exonic

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5190225
Chromosome Location:   7:86792811-86792907question
Amplicon Length:   67

Gene Information

This gene encodes a transcription factor that contains a cyclin D-binding domain three central Myb-like repeats and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Dec 2008]

Gene Symbol:   DMTF1
Gene Name:   cyclin D binding myb-like transcription factor 1
Aliases:   DMP1, DMTF, FLJ25188, FLJ41265, FLJ76054, hDMP1
RefSeq:   NC_000007.13 NT_007933.15
Ensembl:   ENSG00000135164
Entrez:   9988
UniGene:   Hs.196129
Chromosome Mapping:   7q21

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