PrimePCR™ ddPCR™ Expression Probe Assay: PTTG1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0040843; Intron-spanning

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5059080
Chromosome Location:   5:159851301-159854825question
Amplicon Length:   111

Gene Information

The encoded protein is a homolog of yeast securin proteins which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs which are required for its transforming and tumorigenic activities as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein although it partially localizes in the nucleus. [provided by RefSeq Jul 2008]

Gene Symbol:   PTTG1
Gene Name:   pituitary tumor-transforming 1
Aliases:   EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
RefSeq:   NC_000005.9 NT_023133.13
Ensembl:   ENSG00000164611
Entrez:   9232
UniGene:   Hs.350966
Chromosome Mapping:   5q35.1

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