PrimePCR™ ddPCR™ Expression Probe Assay: ESRRG, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0040484; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5058914
Chromosome Location:   1:216692717-216737652question
Amplicon Length:   109

Gene Information

This gene encodes a member of the estrogen receptor-related receptor (ESRR) family which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes co-regulators and promoters and by targeting the same set of genes the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters modulates cell proliferation and estrogen signaling in breast cancer and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq Aug 2011]

Gene Symbol:   ESRRG
Gene Name:   estrogen-related receptor gamma
Aliases:   DKFZp781L1617, ERR3, ERRgamma, FLJ16023, KIAA0832, NR3B3
RefSeq:   NC_000001.10 NT_167186.1
Ensembl:   ENSG00000196482
Entrez:   2104
UniGene:   Hs.444225
Chromosome Mapping:   1q41

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