PrimePCR™ ddPCR™ Expression Probe Assay: PDCD6IP, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0039499; Intron-spanning

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5058688
Chromosome Location:   3:33863536-33866787question
Amplicon Length:   118

Gene Information

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis in intralumenal endosomal vesicle formation and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition the product of this gene binds to the product of the PDCD6 gene a protein required for apoptosis in a calcium-dependent manner. This gene product also binds to endophilins proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq Jan 2012]

Gene Symbol:   PDCD6IP
Gene Name:   programmed cell death 6 interacting protein
Aliases:   AIP1, Alix, DRIP4, HP95, MGC17003
RefSeq:   NC_000003.11 NT_022517.18
Ensembl:   ENSG00000170248
Entrez:   10015
UniGene:   Hs.475896
Chromosome Mapping:   3p22.3

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