PrimePCR™ ddPCR™ Expression Probe Assay: LATS1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0039249; Intron-spanning

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5058525
Chromosome Location:   6:150005624-150016230question
Amplicon Length:   96

Gene Information

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity indicating a role as a negative regulator of CDC2/cyclin A. In addition the C-terminal kinase domain binds to its own N-terminal region suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq Jul 2008]

Gene Symbol:   LATS1
Gene Name:   LATS, large tumor suppressor, homolog 1 (Drosophila)
Aliases:   WARTS, wts
RefSeq:   NC_000006.11 NT_025741.15
Ensembl:   ENSG00000131023
Entrez:   9113
UniGene:   Hs.716697
Chromosome Mapping:   6q25.1

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