PrimePCR™ ddPCR™ Expression Probe Assay: PPM1A, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0033308; Intron-spanning

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5057820
Chromosome Location:   14:60750221-60756539question
Amplicon Length:   138

Gene Information

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53 which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq Jul 2008]

Gene Symbol:   PPM1A
Gene Name:   protein phosphatase, Mg2+/Mn2+ dependent, 1A
Aliases:   FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PP2Calpha
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000100614
Entrez:   5494
UniGene:   Hs.130036
Chromosome Mapping:   14q23.1

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