PrimePCR™ ddPCR™ Expression Probe Assay: UMOD, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0033108; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5057590
Chromosome Location:   16:20348731-20352514question
Amplicon Length:   117

Gene Information

This gene encodes uromodulin the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia gout and progressive renal failure. While several transcript variants may exist for this gene the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq Jul 2008]

Gene Symbol:   UMOD
Gene Name:   uromodulin
RefSeq:   NC_000016.9 NT_010393.16 NG_008151.1
Ensembl:   ENSG00000169344
Entrez:   7369
UniGene:   Hs.654425
Chromosome Mapping:   16p12.3

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