PrimePCR™ ddPCR™ Expression Probe Assay: SHANK2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0033063; Intron-spanning

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5057525
Chromosome Location:   11:70505982-70544812question
Amplicon Length:   148

Gene Information

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction including ankyrin repeats an SH3 domain a PSD-95/Dlg/ZO-1 domain a sterile alpha motif domain and a proline-rich region. This particular family member contains a PDZ domain a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants encoding distinct isoforms are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   SHANK2
Gene Name:   SH3 and multiple ankyrin repeat domains 2
RefSeq:   NC_000011.9 NT_167190.1
Ensembl:   ENSG00000162105
Entrez:   22941
UniGene:   Hs.268726
Chromosome Mapping:   11q13.2

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