PrimePCR™ ddPCR™ Expression Probe Assay: ESPL1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0032992; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5057420
Chromosome Location:   12:53673560-53675376question
Amplicon Length:   147

Gene Information

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1 or separase which initiates the final separation of sister chromatids (Sun et al. 2009 [PubMed 19345191]).[supplied by OMIM Nov 2010]

Gene Symbol:   ESPL1
Gene Name:   extra spindle pole bodies homolog 1 (S. cerevisiae)
Aliases:   ESP1, FLJ46492, KIAA0165
RefSeq:   NC_000012.11 NT_029419.12
Ensembl:   ENSG00000135476
Entrez:   9700
UniGene:   Hs.153479
Chromosome Mapping:   12q

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