PrimePCR™ ddPCR™ Expression Probe Assay: MLH3, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0032937; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5057341
Chromosome Location:   14:75489517-75497299question
Amplicon Length:   103

Gene Information

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified but the full-length nature of only two transcript variants has been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   MLH3
Gene Name:   mutL homolog 3 (E. coli)
Aliases:   HNPCC7, MGC138372
RefSeq:   NC_000014.8 NG_008649.1 NT_026437.12
Ensembl:   ENSG00000119684
Entrez:   27030
UniGene:   Hs.436650
Chromosome Mapping:   14q24.3

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