PrimePCR™ ddPCR™ Expression Probe Assay: HYOU1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0032511; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5057012
Chromosome Location:   11:118920499-118921814question
Amplicon Length:   89

Gene Information

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors especially in breast tumors and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein which is only 3 amino acids shorter than the mature protein in the ER is thought to have a housekeeping function in the cytosol. In rat this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq Oct 2008]

Gene Symbol:   HYOU1
Gene Name:   hypoxia up-regulated 1
Aliases:   DKFZp686N08236, FLJ94899, FLJ97572, Grp170, HSP12A, ORP150
RefSeq:   NC_000011.9 NT_033899.8
Ensembl:   ENSG00000149428
Entrez:   10525
UniGene:   Hs.277704
Chromosome Mapping:   11q23.1-q23.3

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