PrimePCR™ ddPCR™ Expression Probe Assay: LEPR, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0031759; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5056600
Chromosome Location:   1:66036364-66038047question
Amplicon Length:   131

Gene Information

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons however encode distinct proteins (PMID:9207021).[provided by RefSeq Nov 2010]

Gene Symbol:   LEPR
Gene Name:   leptin receptor
Aliases:   CD295, DKFZp686B1731, OBR
RefSeq:   NC_000001.10 NT_032977.9 NG_015831.1
Ensembl:   ENSG00000116678
Entrez:   3953
UniGene:   Hs.723178
Chromosome Mapping:   1p31

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