PrimePCR™ ddPCR™ Expression Probe Assay: DNMT3L, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0031625; Intron-spanning

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5056369
Chromosome Location:   21:45674569-45678445question
Amplicon Length:   118

Gene Information

CpG methylation is an epigenetic modification that is important for embryonic development imprinting and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   DNMT3L
Gene Name:   DNA (cytosine-5-)-methyltransferase 3-like
Aliases:   MGC1090
RefSeq:   NC_000021.8 NT_011515.12
Ensembl:   ENSG00000142182
Entrez:   29947
UniGene:   Hs.592165
Chromosome Mapping:   21q22.3

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