PrimePCR™ ddPCR™ Expression Probe Assay: AXIN2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0031547; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5056229
Chromosome Location:   17:63526141-63530076question
Amplicon Length:   97

Gene Information

The Axin-related protein Axin2 presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway like its rodent homologs mouse conductin/rat axil. In mouse conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon) beta-catenin glycogen synthase kinase 3-beta and conductin which leads to the degradation of beta-catenin. Apparently the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24 a region that shows frequent loss of heterozygosity in breast cancer neuroblastoma and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq Jul 2008]

Gene Symbol:   AXIN2
Gene Name:   axin 2
Aliases:   AXIL, DKFZp781B0869, MGC10366, MGC126582
RefSeq:   NC_000017.10 NG_012142.1 NT_010783.15
Ensembl:   ENSG00000168646
Entrez:   8313
UniGene:   Hs.156527
Chromosome Mapping:   17q23-q24

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