PrimePCR™ ddPCR™ Expression Probe Assay: C5, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0031459; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5056082
Chromosome Location:   9:123794396-123797124question
Amplicon Length:   92

Gene Information

The protein encoded by this gene is the fifth component of complement which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide C5a which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component and this complex is the basis for formation of the membrane attack complex which includes additional complement components. Mutations in this gene cause complement component 5 deficiency a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq Jul 2008]

Gene Symbol:   C5
Gene Name:   complement component 5
Aliases:   CPAMD4, FLJ17816, FLJ17822, MGC142298
RefSeq:   NC_000009.11 NG_007364.1 NT_008470.19
Ensembl:   ENSG00000106804
Entrez:   727
UniGene:   Hs.494997
Chromosome Mapping:   9q33-q34

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