PrimePCR™ ddPCR™ Expression Probe Assay: CLDN18, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0030690; Intron-spanning

 
Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5054649
Chromosome Location:   3:137743542-137749850question
Amplicon Length:   145

Gene Information

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jun 2010]

Gene Symbol:   CLDN18
Gene Name:   claudin 18
Aliases:   DKFZp564B2062, SFTA5, SFTPJ
RefSeq:   NC_000003.11 NT_005612.16
Ensembl:   ENSG00000066405
Entrez:   51208
UniGene:   Hs.655324
Chromosome Mapping:   3q22.3

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