PrimePCR™ ddPCR™ Expression Probe Assay: PDGFB, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0030314; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
Your Price:   Log In
 

Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053930
Chromosome Location:   22:39629472-39631840question
Amplicon Length:   86

Gene Information

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB) where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7 at sites where this gene and that for COL1A1 are located are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq Oct 2008]

Gene Symbol:   PDGFB
Gene Name:   platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Aliases:   FLJ12858, PDGF2, SIS, SSV, c-sis
RefSeq:   NC_000022.10 NG_012111.1 NT_011520.12
Ensembl:   ENSG00000100311
Entrez:   5155
UniGene:   Hs.1976
Chromosome Mapping:   22q12.3-q13.1,22q13.1

Number Description Download