PrimePCR™ ddPCR™ Expression Probe Assay: RBP3, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0030296; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053901
Chromosome Location:   10:48383909-48385906question
Amplicon Length:   108

Gene Information

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity suggesting a series of gene duplication events. In the gene the boundaries of these domains are not defined by exon-intron junctions as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon which is 3180 base pairs long. The remainder of the fourth domain is encoded in the last three exons which are 191 143 and approximately 740 base pairs long respectively. [provided by RefSeq Jul 2008]

Gene Symbol:   RBP3
Gene Name:   retinol binding protein 3, interstitial
Aliases:   D10S64, D10S65, D10S66, IRBP, RBPI
RefSeq:   NC_000010.10 NT_030772.10
Ensembl:   ENSG00000107618
Entrez:   5949
UniGene:   Hs.591928
Chromosome Mapping:   10q11.2

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