PrimePCR™ ddPCR™ Expression Probe Assay: TNFSF11, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0030030; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053396
Chromosome Location:   13:43175019-43180681question
Amplicon Length:   118

Gene Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6 which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq Jul 2008]

Gene Symbol:   TNFSF11
Gene Name:   tumor necrosis factor (ligand) superfamily, member 11
Aliases:   CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
RefSeq:   NC_000013.10 NT_024524.14 NG_008990.1
Ensembl:   ENSG00000120659
Entrez:   8600
UniGene:   Hs.333791
Chromosome Mapping:   13q14

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