This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029834; Intron-spanning
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted whereas oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability renal gene expression profiles and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq Oct 2011]