PrimePCR™ ddPCR™ Expression Probe Assay: LDLR, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029713; Intron-spanning

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052808
Chromosome Location:   19:11224322-11226803question
Amplicon Length:   121

Gene Information

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase the rate-limiting step in cholesterol synthesis. At the same time a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq Sep 2010]

Gene Symbol:   LDLR
Gene Name:   low density lipoprotein receptor
Aliases:   FH, FHC, LDLCQ2
RefSeq:   NC_000019.9 NG_009060.1 NT_011295.11
Ensembl:   ENSG00000130164
Entrez:   3949
UniGene:   Hs.731636
Chromosome Mapping:   19p13.3

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