PrimePCR™ ddPCR™ Expression Probe Assay: SORT1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0029508; Intron-spanning

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052461
Chromosome Location:   1:109867675-109869684question
Amplicon Length:   78

Gene Information

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein a trans-Golgi network (TGN) transmembrane protein binds a number of unrelated ligands that participate in a wide range of cellular processes; however it lacks the typical features of a signalling receptor. In the TGN furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated gamma-adaptin homologous ARF-interacting) proteins. [provided by RefSeq Jul 2008]

Gene Symbol:   SORT1
Gene Name:   sortilin 1
Aliases:   Gp95, LDLCQ6, NT3
RefSeq:   NC_000001.10 NT_032977.9
Ensembl:   ENSG00000134243
Entrez:   6272
UniGene:   Hs.485195
Chromosome Mapping:   1p13.3,1p21.3-p13.1

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