PrimePCR™ ddPCR™ Expression Probe Assay: NOTCH1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0028194; Intron-spanning

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5050283
Chromosome Location:   9:139400286-139401178question
Amplicon Length:   141

Gene Information

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain consisting of multiple different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia notch interaction with its cell-bound ligands (delta serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands and may play multiple roles during development. [provided by RefSeq Jul 2008]

Gene Symbol:   NOTCH1
Gene Name:   notch 1
Aliases:   TAN1, hN1
RefSeq:   NC_000009.11 NG_007458.1 NT_024000.16
Ensembl:   ENSG00000148400
Entrez:   4851
UniGene:   Hs.495473
Chromosome Mapping:   9q34.3

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