PrimePCR™ ddPCR™ Expression Probe Assay: BIN1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0028168; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5050234
Chromosome Location:   2:127828157-127834241question
Amplicon Length:   132

Gene Information

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin synaptojanin endophilin and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq Sep 2011]

Gene Symbol:   BIN1
Gene Name:   bridging integrator 1
Aliases:   AMPH2, AMPHL, DKFZp547F068, MGC10367, SH3P9
RefSeq:   NC_000002.11 NT_022135.16 NG_012042.1
Ensembl:   ENSG00000136717
Entrez:   274
UniGene:   Hs.193163
Chromosome Mapping:   2q14

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