PrimePCR™ ddPCR™ Expression Probe Assay: DMBT1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0028016; Intron-spanning

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049979
Chromosome Location:   10:124396732-124399604question
Amplicon Length:   116

Gene Information

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0 7.5 and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq Jul 2008]

Gene Symbol:   DMBT1
Gene Name:   deleted in malignant brain tumors 1
Aliases:   FLJ61058, GP340, MGC164738, muclin
RefSeq:   NC_000010.10 NT_030059.13 NG_012644.1
Ensembl:   ENSG00000187908
Entrez:   1755
UniGene:   Hs.279611
Chromosome Mapping:   10q26.13

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