PrimePCR™ ddPCR™ Expression Probe Assay: CSTB, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0028008; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049964
Chromosome Location:   21:45194553-45196169question
Amplicon Length:   143

Gene Information

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily including the type 1 cystatins (stefins) type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces inhibiting papain and cathepsins l h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq Jul 2008]

Gene Symbol:   CSTB
Gene Name:   cystatin B (stefin B)
Aliases:   CST6, EPM1, PME, STFB
RefSeq:   NC_000021.8 NG_011545.1 NT_011515.12
Ensembl:   ENSG00000160213
Entrez:   1476
UniGene:   Hs.695
Chromosome Mapping:   21q22.3

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