PrimePCR™ ddPCR™ Expression Probe Assay: ASXL1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027967; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049900
Chromosome Location:   20:30954187-30956886question
Amplicon Length:   122

Gene Information

This gene is similar to the Drosophila additional sex combs gene which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq Sep 2009]

Gene Symbol:   ASXL1
Gene Name:   additional sex combs like 1 (Drosophila)
Aliases:   KIAA0978, MGC117280, MGC71111
RefSeq:   NC_000020.10 NT_011362.10 NG_027868.1
Ensembl:   ENSG00000171456
Entrez:   171023
UniGene:   Hs.374043
Chromosome Mapping:   20q11.1

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