PrimePCR™ ddPCR™ Expression Probe Assay: PTRF, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027951; Intron-spanning

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049876
Chromosome Location:   17:40557386-40574739question
Amplicon Length:   86

Gene Information

This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq Nov 2009]

Gene Symbol:   PTRF
Gene Name:   polymerase I and transcript release factor
Aliases:   CAVIN, CAVIN1, CGL4, FLJ90031, cavin-1
RefSeq:   NC_000017.10 NG_015845.1 NT_010783.15
Ensembl:   ENSG00000177469
Entrez:   284119
UniGene:   Hs.437191
Chromosome Mapping:   17q21.2

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