PrimePCR™ ddPCR™ Expression Probe Assay: TDP1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027904; Intron-spanning

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049793
Chromosome Location:   14:90433734-90442142question
Amplicon Length:   117

Gene Information

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq Jul 2008]

Gene Symbol:   TDP1
Gene Name:   tyrosyl-DNA phosphodiesterase 1
Aliases:   FLJ11090, MGC104252
RefSeq:   NC_000014.8 NT_026437.12 NG_009164.1
Ensembl:   ENSG00000042088
Entrez:   55775
UniGene:   Hs.209945
Chromosome Mapping:   14q32.11

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