PrimePCR™ ddPCR™ Expression Probe Assay: TNNT1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027881; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049749
Chromosome Location:   19:55649394-55652585question
Amplicon Length:   129

Gene Information

This gene encodes a protein that is a subunit of troponin which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C which binds calcium troponin T which binds tropomyosin and troponin I which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5 also known as Amish nemaline myopathy a neuromuscular disorder characterized by muscle weakness and rod-shaped or nemaline inclusions in skeletal muscle fibers which affects infants resulting in death due to respiratory insufficiency usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   TNNT1
Gene Name:   troponin T type 1 (skeletal, slow)
Aliases:   ANM, FLJ98147, MGC104241, STNT, TNT, TNTS
RefSeq:   NC_000019.9 NT_011109.16 NG_011829.1
Ensembl:   ENSG00000105048
Entrez:   7138
UniGene:   Hs.631558
Chromosome Mapping:   19q13.4

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