PrimePCR™ ddPCR™ Expression Probe Assay: CHRNG, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027732; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049490
Chromosome Location:   2:233409579-233410350question
Amplicon Length:   102

Gene Information

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits one beta one delta and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene which encodes the gamma subunit is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq Sep 2009]

Gene Symbol:   CHRNG
Gene Name:   cholinergic receptor, nicotinic, gamma
Aliases:   ACHRG, MGC133376
RefSeq:   NC_000002.11 NG_012954.1 NT_005403.17
Ensembl:   ENSG00000196811
Entrez:   1146
UniGene:   Hs.248101
Chromosome Mapping:   2q33-q34

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