PrimePCR™ ddPCR™ Expression Probe Assay: NCOA2, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027721; Intron-spanning

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049471
Chromosome Location:   8:71044168-71050536question
Amplicon Length:   139

Gene Information

The NCOA2 gene encodes nuclear receptor coactivator 2 which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth development and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily which includes the 5 steroid receptors and class II nuclear receptors (see below) are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain a central DNA-binding domain and a C-terminal hormone-binding domain. Before the binding of hormone steroid receptors which are sometimes called class I of the nuclear hormone receptor family remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex bind as homodimers to specific DNA enhancer elements associated with target genes and modulate that gene's transcription. After binding to enhancer elements transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al. 1997 [PubMed 9111344]).[supplied by OMIM Nov 2010]

Gene Symbol:   NCOA2
Gene Name:   nuclear receptor coactivator 2
Aliases:   GRIP1, KAT13C, MGC138808, NCoA-2, SRC2, TIF2, bHLHe75
RefSeq:   NC_000008.10 NT_008183.19
Ensembl:   ENSG00000140396
Entrez:   10499
UniGene:   Hs.446678
Chromosome Mapping:   8q13.3

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