PrimePCR™ ddPCR™ Expression Probe Assay: LDB2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027720; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049469
Chromosome Location:   4:16590409-16597427question
Amplicon Length:   119

Gene Information

Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al. 1998 [PubMed 9799849]). These proteins such as the one encoded by the LDB2 gene are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse Clim1 (Bach et al. 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al. 1996 [PubMed 8918878]; Jurata et al. 1996 [PubMed 8876198]; Bach et al. 1997 [PubMed 9192866]) and their homologs cloned from the frog chicken and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM Jul 2010]

Gene Symbol:   LDB2
Gene Name:   LIM domain binding 2
Aliases:   CLIM1, LDB1
RefSeq:   NC_000004.11 NT_006316.16
Ensembl:   ENSG00000169744
Entrez:   9079
UniGene:   Hs.714330
Chromosome Mapping:   4p16

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