PrimePCR™ ddPCR™ Expression Probe Assay: SEMA4A, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027543; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049144
Chromosome Location:   1:156128510-156130292question
Amplicon Length:   135

Gene Information

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions including axon guidance morphogenesis carcinogenesis and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq Sep 2010]

Gene Symbol:   SEMA4A
Gene Name:   sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Aliases:   CORD10, FLJ12287, RP35, SEMAB, SEMB
RefSeq:   NC_000001.10 NT_004487.19 NG_027683.1
Ensembl:   ENSG00000196189
Entrez:   64218
UniGene:   Hs.408846
Chromosome Mapping:   1q22

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