PrimePCR™ ddPCR™ Expression Probe Assay: LRP6, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027498; Intron-spanning

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5049061
Chromosome Location:   12:12274256-12277540question
Amplicon Length:   111

Gene Information

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or with Frizzled a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation proliferation and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq Dec 2009]

Gene Symbol:   LRP6
Gene Name:   low density lipoprotein receptor-related protein 6
Aliases:   ADCAD2, FLJ90062, FLJ90421
RefSeq:   NC_000012.11 NG_016168.1 NT_009714.17
Ensembl:   ENSG00000070018
Entrez:   4040
UniGene:   Hs.584775
Chromosome Mapping:   12p13.2

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