PrimePCR™ ddPCR™ Expression Probe Assay: AXIN1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027462; Intron-spanning

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048999
Chromosome Location:   16:364629-396210question
Amplicon Length:   88

Gene Information

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli catenin beta-1 glycogen synthase kinase 3 beta protein phosphate 2 and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein alone and in a complex with other proteins has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma hepatoblastomas ovarian endometriod adenocarcinomas and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq Dec 2010]

Gene Symbol:   AXIN1
Gene Name:   axin 1
Aliases:   AXIN, MGC52315
RefSeq:   NC_000016.9 NG_012267.1 NT_010393.16
Ensembl:   ENSG00000103126
Entrez:   8312
UniGene:   Hs.592082
Chromosome Mapping:   16p13.3

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