PrimePCR™ ddPCR™ Expression Probe Assay: ANGPTL4, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027370; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048861
Chromosome Location:   19:8434135-8435993question
Amplicon Length:   106

Gene Information

This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis lipid metabolism and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq Jul 2008]

Gene Symbol:   ANGPTL4
Gene Name:   angiopoietin-like 4
Aliases:   ANGPTL2, ARP4, FIAF, HFARP, NL2, PGAR, pp1158
RefSeq:   NC_000019.9 NT_077812.2 NG_012169.1
Ensembl:   ENSG00000167772
Entrez:   51129
UniGene:   Hs.9613
Chromosome Mapping:   19p13.3

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