PrimePCR™ ddPCR™ Expression Probe Assay: BCL10, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027324; Intron-spanning

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048790
Chromosome Location:   1:85733627-85736418question
Amplicon Length:   127

Gene Information

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD) and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9 10 11 and 14 which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1 a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq Jul 2008]

Gene Symbol:   BCL10
Gene Name:   B-cell CLL/lymphoma 10
Aliases:   CARMEN, CIPER, CLAP, c-E10, mE10
RefSeq:   NC_000001.10 NG_012216.1 NT_032977.9
Ensembl:   ENSG00000142867
Entrez:   8915
UniGene:   Hs.193516
Chromosome Mapping:   1p22

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