PrimePCR™ ddPCR™ Expression Probe Assay: PSEN2, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027160; Intron-spanning

 
Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048529
Chromosome Location:   1:227073358-227076584question
Amplicon Length:   116

Gene Information

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase an enzyme that cleaves APP. Also it is thought that the presenilins are involved in the cleavage of the Notch receptor such that they either directly regulate gamma-secretase activity or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   PSEN2
Gene Name:   presenilin 2 (Alzheimer disease 4)
Aliases:   AD3L, AD4, CMD1V, PS2, STM2
RefSeq:   NC_000001.10 NG_007381.1 NT_167186.1
Ensembl:   ENSG00000143801
Entrez:   5664
UniGene:   Hs.25363
Chromosome Mapping:   1q31-q42

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