PrimePCR™ ddPCR™ Expression Probe Assay: SERPINB8, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026246; Intron-spanning

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5046917
Chromosome Location:   18:61647096-61649033question
Amplicon Length:   126

Gene Information

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation fibrinolysis coagulation cellular differentiation tumor suppression apoptosis and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell 1989 [PubMed 2690952]). A critical portion of the molecule the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily which relative to the archetypal serpin PI1 (MIM 107400) is characterized by a high degree of homology to chicken ovalbumin lack of N- and C-terminal extensions absence of a signal peptide and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al. 1997 [PubMed 9268635]).[supplied by OMIM Jan 2010]

Gene Symbol:   SERPINB8
Gene Name:   serpin peptidase inhibitor, clade B (ovalbumin), member 8
Aliases:   CAP2, PI8
RefSeq:   NC_000018.9 NT_025028.14
Ensembl:   ENSG00000166401
Entrez:   5271
UniGene:   Hs.368077
Chromosome Mapping:   18q21.3

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