PrimePCR™ ddPCR™ Expression Probe Assay: TFE3, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0026212; Intron-spanning

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5046852
Chromosome Location:   X:48891723-48895629question
Amplicon Length:   109

Gene Information

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF TFE3 TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3 SMAD3 and LEF-1 and is involved in TGF-beta-induced transcription playing important roles in cell growth proliferation and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas such as PRCC-TFE3 RCC17-TFE3 PSF-TFE3 NonO (p54nrb)-TFE3 and ASPL-TFE3.[provided by RefSeq Dec 2009]

Gene Symbol:   TFE3
Gene Name:   transcription factor binding to IGHM enhancer 3
Aliases:   RCCP2, TFEA, bHLHe33
RefSeq:   NC_000023.10 NG_016297.1 NT_079573.4
Ensembl:   ENSG00000068323
Entrez:   7030
UniGene:   Hs.730740
Chromosome Mapping:   Xp11.22

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