PrimePCR™ ddPCR™ Expression Probe Assay: PSEN1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0058435; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5046065
Chromosome Location:   14:73603283-73614687question
Amplicon Length:   74

Gene Information

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase an enzyme that cleaves APP. Also it is thought that the presenilins are involved in the cleavage of the Notch receptor such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene the full-length nature of only some have been determined. [provided by RefSeq Aug 2008]

Gene Symbol:   PSEN1
Gene Name:   presenilin 1
Aliases:   AD3, FAD, PS-1, PS1, S182
RefSeq:   NC_000014.8 NG_007386.2 NT_026437.12
Ensembl:   ENSG00000080815
Entrez:   5663
UniGene:   Hs.3260
Chromosome Mapping:   14q24.3

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